Overseas, Sony's "The Amazing Spider-Man" added $129.1 million, raising its international total to $201.6 million and worldwide haul to $341.2 million since it began rolling out a week earlier in some foreign markets.
The movie started off as a smaller domestic moneymaker than the previous three Spidey films, but it laid to rest objections that it was too soon to relaunch the superhero franchise.
The new origin story for the Marvel Comics web-slinger comes just five years after "Spider-Man 3," Tobey Maguire and director Sam Raimi's final movie in a series that shattered box-office records.
"This was never modeled or was never meant to be 'Spider-Man 4.' This was always a relaunch with a new cast and different stories to tell, and quite frankly, it succeeded beyond our imaginations," said Rory Bruer, Sony's head of distribution.